In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation

Opt Lett. 2018 Jun 1;43(11):2450-2453. doi: 10.1364/OL.43.002450.

Abstract

We demonstrate time domain diffuse correlation spectroscopy at quasi-null source-detector separation by using a fast time-gated single-photon avalanche diode without the need of time-tagging electronics. This approach allows for increased photon collection, simplified real-time instrumentation, and reduced probe dimensions. Depth discriminating, quasi-null distance measurement of blood flow in a human subject is presented. We envision the miniaturization and integration of matrices of optical sensors of increased spatial resolution and the enhancement of the contrast of local blood flow changes.

MeSH terms

  • Adult
  • Blood Flow Velocity / physiology*
  • Female
  • Humans
  • Optical Fibers
  • Photons
  • Scattering, Radiation
  • Spectrum Analysis / methods*