Abstract
A new dimeric naphtho-γ-pyrone, asperpyrone F (1), along with six known ones, asperpyrones B (2) and C (3), fonsecinones A (4) and B (5), aurasperones A (6) and E (7), have been isolated from the solid culture of the edible fungus Pleurotus ostreatus. The structures of 1-7 were determined mainly by NMR and MS experiments. The absolute configuration of compound 1 was assigned via the circular dichroism (CD) data analysis. Compounds 1-7 showed modest antioxidant and immunomodulatory activities. All compounds were isolated from the fungus P. ostreatus for the first time.
Keywords:
antioxidant activity; bis-naphtho--pyrone; immunomodulatory activity.
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Chromones / chemistry
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Chromones / isolation & purification
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Chromones / pharmacology
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Circular Dichroism
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Drug Evaluation, Preclinical / methods
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Immunologic Factors / chemistry
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Immunologic Factors / isolation & purification
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Immunologic Factors / pharmacology
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Magnetic Resonance Spectroscopy
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Mice
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Molecular Structure
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Pleurotus / chemistry*
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Pleurotus / metabolism
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / pharmacology
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RAW 264.7 Cells
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Secondary Metabolism
Substances
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Antioxidants
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Chromones
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Immunologic Factors
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Pyrones
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fonsecinone A