MicroRNA-155 Regulates Inflammatory Response in Ischemic Cerebral Tissues through Autophagy

Abstract

Our previous work has indicated that miR-155 expression induces inflammatory responses in ischemic cerebral tissues. However, the delicate regulation of miR-155-modifed inflammatory responses has remained enigmatic. In the present study, we found that autophagy is induced by ischemia through miR-155 and involved in neural injury. Subsequently, miR-155- induced autophagy modifies inflammatory responses through regulating TLR4/NF-κB pathway in ischemic cerebral tissues. Thus, miR-155 elevated autophagy is detrimental for ischemic cerebral injury and miR-155-induced autophagy modulates inflammatory responses through activating TLR4/NF-κB pathway.

Keywords: autophagy; hypoxic damages; inflammatory response; ischemic cerebral tissues; ischemic stroke; miR-155..