Two new monoterpene glucosides from Xanthium strumarium subsp. sibiricum with their anti-inflammatory activity

Hai Jiang; Xudong Xing; Meiling Yan; Xinyue Guo; Lin Yang; Liu Yang

doi:10.1080/14786419.2018.1479701

Two new monoterpene glucosides from Xanthium strumarium subsp. sibiricum with their anti-inflammatory activity

Nat Prod Res. 2019 Dec;33(23):3383-3388. doi: 10.1080/14786419.2018.1479701. Epub 2018 Jun 1.

Authors

Hai Jiang¹, Xudong Xing¹, Meiling Yan¹, Xinyue Guo¹, Lin Yang¹, Liu Yang¹

Affiliation

¹ Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education , Harbin , PR China.

PMID: 29852790
DOI: 10.1080/14786419.2018.1479701

Abstract

Two new monoterpene glucosides: xanmonoter A (1) and xanmonoter B (2) were isolated from Xanthium strumarium. Their structures were elucidated on the basis of 1D and 2D NMR, MS and CD analysis. Compounds 1 and 2 were tested for their anti-inflammatory activity with IC₅₀ values of 17.4, 22.1 μM, respectively.

Keywords: antiinflammatory activity; monoterpene glucosides.

Publication types

Video-Audio Media

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry*
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Circular Dichroism
Drug Evaluation, Preclinical
Glucosides / chemistry
Lipopolysaccharides / toxicity
Macrophages / drug effects
Macrophages / metabolism
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Monoterpenes / chemistry*
Monoterpenes / pharmacology*
Nitric Oxide / metabolism
RAW 264.7 Cells
Spectrometry, Mass, Electrospray Ionization
Xanthium / chemistry*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Glucosides
Lipopolysaccharides
Monoterpenes
Nitric Oxide