Immunodominance hierarchy of influenza subtype-specific neutralizing antibody response as a hurdle to effectiveness of polyvalent vaccine

Hum Vaccin Immunother. 2018;14(10):2537-2539. doi: 10.1080/21645515.2018.1482172. Epub 2018 Jun 28.

Abstract

Strengthening of immunodominance hierarchy of influenza subtype-specific neutralizing antibody response by annual polyvalent vaccinations could increase the variation of vaccine effectiveness by subtype. Therefore, we suggest the assessment of neutralizing antibody titer prior to seasonal vaccination and recommend the inoculation of only strains lower than protective levels.

Keywords: Influenza; immunodominance hierarchy; vaccine effectiveness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Neutralizing / blood*
  • Antibodies, Viral / blood*
  • Humans
  • Immunization Schedule*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology*
  • Influenza, Human / prevention & control*

Substances

  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Influenza Vaccines

Grants and funding

This research was supported by the Korea Institute of Oriental Medicine (C18010). We thank Prof. Sang Heui Seo (Chungnam National University) for providing insight and expertise that greatly assisted the research.