Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme

Giedre Kasparaviciene; Zenona Kalveniene; Alvydas Pavilonis; Ruta Marksiene; Jurgita Dauksiene; Jurga Bernatoniene

doi:10.1155/2018/9431819

Formulation and Characterization of Potential Antifungal Oleogel with Essential Oil of Thyme

Evid Based Complement Alternat Med. 2018 Apr 19:2018:9431819. doi: 10.1155/2018/9431819. eCollection 2018.

Authors

Giedre Kasparaviciene^{1

2}, Zenona Kalveniene^{1

2}, Alvydas Pavilonis³, Ruta Marksiene⁴, Jurgita Dauksiene¹, Jurga Bernatoniene^{1

2}

Affiliations

¹ Department of Drug Technology and Social Pharmacy, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, Lithuania.
² Institute of Pharmaceutical Technologies, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, Lithuania.
³ Institute of Microbiology and Virology, Lithuanian University of Health Sciences, Eiveniu Str. 4, LT-50161 Kaunas, Lithuania.
⁴ Department of Analytical and Toxicological Chemistry, Lithuanian University of Health Sciences, Sukileliu Pr. 13, LT-50161 Kaunas, Lithuania.

Abstract

The aim of this research was to formulate oleogel with thyme essential oil with potential antimicrobial activity, design optimal formulation, and evaluate the influence of ingredients on texture parameters of preparation. Central composite design was applied to statistical optimization of colloidal silica and paraffin oil mixture for the modeling of oleogel delivery system. The influence of designed formulations on response variables (texture parameters), firmness, cohesiveness, consistency, and index of viscosity, was evaluated. Quality of essential oil of thyme was assessed by determinate concentration of thymol and carvacrol using gas chromatography with flame ionization detection (GC-FID). Microbiological tests have shown that oleogel with thyme essential oil affects Candida albicans microorganism when thyme essential oil's concentration is 0,05% in oleogel mixture.