A Practical and Chemoselective Ammonia-Free Birch Reduction

Org Lett. 2018 Jun 15;20(12):3439-3442. doi: 10.1021/acs.orglett.8b00891. Epub 2018 May 30.

Abstract

A novel protocol for a significantly improved, practical, and chemoselective ammonia-free Birch reduction mediated by bench-stable sodium dispersions and recoverable 15-crown-5 ether is reported. A broad range of aromatic and heteroaromatic compounds is reduced with excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't