Two new echinocystic acid derivatives catalyzed by filamentous fungus Gliocladium roseum CGMCC 3.3657

Shao-Bin Fu; Xu Feng; Qing-Feng Meng; Qing Cai; Di-An Sun

doi:10.1080/14786419.2018.1477148

Two new echinocystic acid derivatives catalyzed by filamentous fungus Gliocladium roseum CGMCC 3.3657

Nat Prod Res. 2019 Jul;33(13):1842-1848. doi: 10.1080/14786419.2018.1477148. Epub 2018 May 29.

Authors

Shao-Bin Fu^{1

2}, Xu Feng^{1

3}, Qing-Feng Meng⁴, Qing Cai², Di-An Sun¹

Affiliations

¹ a Institute of Medical Plant Development , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
² b Pharmacy School of Zunyi Medical University , Zunyi , China.
³ c Navy Medical Research Institute , Shanghai , China.
⁴ d Department of Public Health , Zunyi Medical University , Zunyi , China.

PMID: 29842795
DOI: 10.1080/14786419.2018.1477148

Abstract

Biotransformation of Echinocystic acid (EA,1) using G. roseum CGMCC 3.3657 has been investigated, which leads to the isolation and identification of two novel Echinocystic acid derivatives, 4, 16α-dihydroxy-3,4-seco-olean-12-en-3,28-dioic acid (2) and 16α-hydroxy, A-homo-3α-oxa-olean-12-en-3-one-28-oic acid (3). Their structures have been elucidated by analysis of spectroscopic data. This biocatalysis could serve as an efficient tool complementary to classical chemical methods for the transformation of EA.

Keywords: CGMCC 3.3657; Echinocystic acid; biotransformation; pentacyclictriterpene; structure modification.

MeSH terms

Biotransformation*
Catalysis
Gliocladium / metabolism*
Molecular Structure
Oleanolic Acid / analogs & derivatives*
Oleanolic Acid / chemistry
Spectrum Analysis

Substances

Oleanolic Acid
echinocystic acid