First report of Nitzschia navis-varingica in the Mediterranean Sea and growth stimulatory effects of Nitzschia navis-varingica, Chrysochromulina alifera and Heterocapsa pygmaea on different mammalian cell types

Mol Biol Rep. 2018 Aug;45(4):571-579. doi: 10.1007/s11033-018-4195-7. Epub 2018 May 28.

Abstract

A benthic diatom, Nitzschia navis-varingica was found for the first time in the Mediterranean Sea. Effects of this diatom species together with the haptophyte Chrysochromulina alifera and the dinoflagellate Heterocapsa pygmaea isolated from the northeastern Mediterranean Sea coast on prostate, breast cancer and fibroblast cell lines were investigated. Algal extracts did not exert any toxic effect on these cell lines and it had growth stimulatory impact on the cells without discrimination of cell type. Our results suggest potential use of these algal extracts in tissue repair and cell growth boosting additive in the diet of humans as well as animals. Moreover, these algal extracts have potential to be used as natural resource in the skin vitalizing creams of cosmetics industry and as wound healing agents in the atopic drugs.

Keywords: Growth stimulatory molecules; Microalgae; Natural cosmetics; Natural drugs.

MeSH terms

  • Animals
  • Cell Line, Tumor / drug effects*
  • Diatoms / metabolism*
  • Dinoflagellida / metabolism
  • Growth Substances / metabolism
  • Haptophyta / metabolism
  • Humans
  • Mediterranean Sea
  • Phytoplankton / metabolism

Substances

  • Growth Substances