Rad5, HLTF, and SHPRH: A Fresh View of an Old Story

Menattallah Elserafy; Arwa A Abugable; Reham Atteya; Sherif F El-Khamisy

doi:10.1016/j.tig.2018.04.006

Rad5, HLTF, and SHPRH: A Fresh View of an Old Story

Trends Genet. 2018 Aug;34(8):574-577. doi: 10.1016/j.tig.2018.04.006. Epub 2018 May 26.

Authors

Menattallah Elserafy¹, Arwa A Abugable², Reham Atteya³, Sherif F El-Khamisy⁴

Affiliations

¹ Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt; These authors contributed equally to the manuscript.
² Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt; These authors contributed equally to the manuscript.
³ Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt.
⁴ Krebs Institute, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield S10 2TN, UK; Center for Genomics, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Giza 12578, Egypt. Electronic address: s.el-khamisy@sheffield.ac.uk.

Abstract

Not only have helicase-like transcription factor (HLTF) and SNF2 histone-linker PHD-finger RING-finger helicase (SHPRH) proved to be important players in post-replication repair like their yeast counterpart, Rad5, but they are also involved in multiple biological functions and are associated with several human disorders. We provide here an updated view of their functions, associated diseases, and potential therapeutic approaches.

Keywords: HIV-1; HLTF; RAD5; SHPRH; bowel disease; cancer.

Publication types

Review

MeSH terms

Animals
DNA Helicases / chemistry
DNA Helicases / genetics
DNA Helicases / metabolism*
DNA-Binding Proteins / chemistry
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism*
Disease Susceptibility
Gene Expression Regulation
Humans
Signal Transduction
Transcription Factors / chemistry
Transcription Factors / genetics
Transcription Factors / metabolism*
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism*

Substances

DNA-Binding Proteins
HLTF protein, human
Transcription Factors
SHPRH protein, human
Ubiquitin-Protein Ligases
DNA Helicases