Human cytomegalovirus replication induces endothelial cell interleukin-11

Cytokine. 2018 Nov:111:563-566. doi: 10.1016/j.cyto.2018.05.018. Epub 2018 May 25.

Abstract

Endothelial cells (EC) are critical sites of human cytomegalovirus (hCMV) infection in vivo. Infection can induce the production of various EC cytokines, such as interleukin (IL-)6, which can have autocrine and/or paracrine effector functions. Here, we report that hCMV induces the production of EC IL-11, a relatively understudied member of the IL-6-type cytokine family. We detail temporal EC IL-11 translation and protein secretion dynamics in response to hCMV infection, and reveal distinct differences compared to EC IL-6. Viral replication had markedly opposing effects on the regulation of these closely related cytokines, representing a major driving force behind IL-11 production, whilst concurrently suppressing IL-6 expression. This is the first report of any biological agent that stimulates EC IL-11 production.

Keywords: Cytomegalovirus; Endothelial cell; Interleukin 11; Interleukin 6.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Cytokines / metabolism
  • Cytomegalovirus / genetics*
  • Cytomegalovirus Infections / metabolism*
  • Cytomegalovirus Infections / virology
  • Endothelial Cells / metabolism*
  • Endothelial Cells / virology*
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Interleukin-11 / metabolism*
  • Virus Replication / genetics*

Substances

  • Cytokines
  • IL11 protein, human
  • Interleukin-11