Cross-linked and hydrophobized hyaluronic acid-based controlled drug release systems

Edit Csapó; Hajnalka Szokolai; Ádám Juhász; Norbert Varga; László Janovák; Imre Dékány

doi:10.1016/j.carbpol.2018.04.073

Cross-linked and hydrophobized hyaluronic acid-based controlled drug release systems

Carbohydr Polym. 2018 Sep 1:195:99-106. doi: 10.1016/j.carbpol.2018.04.073. Epub 2018 Apr 22.

Authors

Edit Csapó¹, Hajnalka Szokolai², Ádám Juhász³, Norbert Varga², László Janovák², Imre Dékány³

Affiliations

¹ MTA-SZTE Biomimetic Systems Research Group, Department of Medical Chemistry, Faculty of Medicine, University of Szeged, H-6720, Dóm square 8, Szeged, Hungary; Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Aradi v.t.1, Szeged, Hungary. Electronic address: juhaszne.csapo.edit@med.u-szeged.hu.
² Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Aradi v.t.1, Szeged, Hungary.
³ MTA-SZTE Biomimetic Systems Research Group, Department of Medical Chemistry, Faculty of Medicine, University of Szeged, H-6720, Dóm square 8, Szeged, Hungary; Department of Physical Chemistry and Materials Science, University of Szeged, H-6720, Aradi v.t.1, Szeged, Hungary.

PMID: 29805030
DOI: 10.1016/j.carbpol.2018.04.073

Abstract

This work demonstrates the preparation, structural characterization, and the kinetics of the drug release of hyaluronic acid (HyA)-based colloidal drug delivery systems which contain hydrophobic ketoprofen (KP) as model molecule. Because of the highly hydrophilic character of HyA the cross-linked derivatives at different cross-linking ratio have been synthesized. The hydrophobized variants of HyA have also been produced by modifying the polymer chains with cetyltrimethylammonium bromide (CTAB) at various HyA/CTAB ratios. Due to modifications the coherent structure of HyA changes into an incoherent colloidal system that were verified by rheological investigations. Nearly 70% of the encapsulated KP dissolve from the totally cross-linked HyA carrier but the release rate of KP is about 20% (after 8 h) from the CTAB-modified colloidal system at HyA monomer/CTAB 1:0.8 mass ratio. It has been verified that the modified HyA may be a potential candidate for controlled drug release of hydrophobic KP molecules.

Keywords: Hyaluronic acid; Nanocarrier; Rheology; controlled drug release; cross-linkingCross-linking; hydrophobizationHydrophobization.