Cystic nephroma is an unusual, cystic neoplasm of the kidney and is usually benign. There are two peaks in the incidence of the tumor, with a bimodal distribution presenting in children younger than two years old and in adults. These benign lesions are usually seen in childhood, whose clinical presentation is nonspecific with symptoms such as flank pain, hematuria and urinary tract infection. We aim to report treatment, and follow-up of a 48-year-old female patient with cystic nephroma for whom we performed open partial nephrectomy. As a surgical treatment radical or partial nephrectomy is applied according to the size and position of the masses. Long-term follow-up is recommended to rule out local recurrence or metastasis.