Abstract
Dendrimers possess intriguing "dendritic effects", which are unique characteristics that stem from the dendrimer generation and size. Here we report a "negative dendritic effect" observed during enzymatic hydrolysis of dendrimer conjugates. Such negative dendritic effects, though rarely reported, may be explored for tailored and generation-dependent drug release.
MeSH terms
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Animals
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Carboxylic Ester Hydrolases / chemistry*
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Cattle
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Click Chemistry
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Dendrimers / chemical synthesis
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Dendrimers / chemistry
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Dendrimers / metabolism*
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry
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Drug Carriers / metabolism*
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Drug Liberation
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Esters / chemical synthesis
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Esters / chemistry
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Esters / metabolism
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Hydrolysis
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Molecular Structure
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Swine
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / metabolism
Substances
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Dendrimers
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Drug Carriers
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Esters
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Triazoles
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Carboxylic Ester Hydrolases