Abstract
Total synthesis of jahanyne (1) was achieved from commercially available materials on a 38 mg scale. The Boc- N-Me- L-Val-OH fragment along with the HATU/DIPEA coupling condition was applied to avoid the diketopiperazine side reaction in solution phase synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Diketopiperazines / chemistry
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HeLa Cells
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Humans
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Lipopeptides / chemical synthesis*
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Lipopeptides / chemistry
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Methylation
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Spectrum Analysis / methods
Substances
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Diketopiperazines
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Lipopeptides
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jahanyne