Objective: To summarize the research progress of microRNA (miRNA) and its non-viral vector in intervertebral disc degeneration (IDD) and to investigate the potential of non-viral vector delivery of miRNA in clinical application.
Methods: The related literature about the role of miRNA in IDD and its non-viral delivery system was reviewed and analyzed.
Results: MiRNA can regulate the related gene expression level and further participate in the pathophysiologic process in degenerated intervertebral disc, miRNA delivered by various non-viral vectors has obtained an ideal effect in some diseases.
Conclusion: MiRNA plays a great role in the cellular and molecular mechanisms of IDD, as a safe and effective strategy for gene therapy, non-viral vector provides new possibilities for IDD treated with miRNA.
目的: 总结椎间盘退变（intervertebral disc degeneration，IDD）中微小 RNA（microRNA，miRNA）及其非病毒载体的研究进展，探讨非病毒载体递送miRNA的临床应用潜能，为 IDD 治疗提供新思路。.
方法: 广泛查阅国内外有关 miRNA 在 IDD 中作用及其非病毒载体相关的文献并进行总结分析。.
结果: 退变椎间盘组织中明显差异性表达的 miRNA 通过对基因表达的调控参与多种病理生理过程，许多类型非病毒载体递送 miRNA 的基因治疗方式在一些疾病治疗中已取得了理想效果。.
结论: miRNA 在 IDD 细胞分子机制中发挥重要作用，非病毒载体作为一种安全有效的基因治疗策略，为通过 miRNA 治疗 IDD 提供了新的可能。.
Keywords: Intervertebral disc degeneration; gene therapy; microRNA; non-viral vector.