Objective: To review the current status and advances of the correlation between traumatic brain injury (TBI) and fracture healing.
Methods: The related domestic and abroad literature about the correlation between TBI and fracture healing was extensively reviewed and analyzed.
Results: There are a variety of studies on the correlation between TBI and fracture healing, which can be divided into two major aspects: revascularization and osteogenesis; the local and systemic changes of the neuropeptide and hormone after TBI.
Conclusion: TBI facilitates callus formation, the further research is needed to clarify the exact mechanism.
目的: 总结创伤性脑外伤（traumatic brain injury，TBI）对骨折愈合影响机制研究的进展。.
方法: 广泛查阅国内外有关 TBI 对骨折愈合影响的文献，并进行总结分析。.
结果: TBI 影响骨折愈合机制复杂，研究方向可大致分为骨折愈合过程中血管生成及骨再生的调节，以及脑外伤后神经肽及相关激素反应后的局部和全身变化。.
结论: TBI 对骨折愈合起促进作用，其确切作用机制有待进一步研究。.
Keywords: Traumatic brain injury; fracture healing; mechanism.