MiRNA(miR) is a non-coding small RNA of 18 to 24 nucleotides in length.By pairing with 3'UTR of its target mRNA molecule, miRNA regulateS the target mRNA molecule in the translation level or directly lead to its degradation. Each miRNA may target several to several hundred mRNAs, of which 30% of the mRNA is regulated by miRNAs. Some studies have shown that miRNA expression disorders play an important role in the development and progression of various tumors and may be the ideal target for tumor therapy. It has been shown that abnormal expression of RNA (miRNA) plays an important role in the occurrence and development of laryngeal cancer. Wang Ping found 47 kinds of miRNA expression abnormalities in laryngeal cancer tissue with microarray chip detection, that of which high expression were 23 kinds and low expression were 24 kinds. MiRNAs that are abnormally expressed in laryngeal squamous cell carcinoma are expected to be a new marker for early diagnosis of laryngeal cancer. In this review, we summarized the progress in recent three years on the association of miRNA and the biological behaviors of laryngeal cancer.
Keywords: laryngeal carcinoma; microRNA; pathogenesis.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.