Objective:To investigate the effects of serum lactate dehydrogenase (LDH) and serum alkaline phosphatase (ALP) levels on the prognosis of patients with nasopharyngeal carcinoma (NPC) before treatment.Method:Three hundred and thirty nine NPC cases, who were firstly treated in our hospital from April 2006 to October 2008, were enrolled in our study. Association of overall survival (OS) rate and disease-free survival (DFS) rate with clinical characteristics (age, gender, Tclassification, Nclassification, clinicalstage, radio therapy methods, radio therapy dose, the levels of pretreatment serum LDH) were evaluated using univariate and multivariate analysis methods.Result:Univariate analysis showed that age, clinical stage, pretreatment LDH level were significantly associated with OS and DFS of NPC. And multivariate analysis revealed that age, clinical stage and pretreatment LDH level were independent factors for OS and DFS.Conclusion:Age, clinical stage and the levels of pretreatment LDH level may be independent prognostic factorsto predict recurrence and death of NPC.
Keywords: ALP; LDH; disease free survival; nasopharyngeal carcinoma; overall survival; prognosis.
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