Effect of Coenzyme Q10 on Expression of UbiAd1 Gene in Rat Model of Local Cerebral Ischemia

Bull Exp Biol Med. 2018 May;165(1):69-71. doi: 10.1007/s10517-018-4101-2. Epub 2018 May 24.

Abstract

The study examined the effect of endogenous lipid-soluble antioxidant coenzyme Q10 on the expression of UbiA gene of prenyltransferase domain-containing protein 1 (UbiAd1) involved in synthesis of vitamin K2 (and probably of coenzyme Q10) on a rat model of ischemic stroke provoked by ligation of the middle cerebral artery in the left hemisphere. Ischemia enhanced expression of mRNA of UbiAd1 gene in both cerebral hemispheres, but the effect was significant only in the contralateral one. The study revealed no effect of intraperitoneal injection of coenzyme Q10 (30 mg/kg) on ischemia-produced elevation of mRNA of UbiAd1 gene. Further studies are needed to assess possible neuroprotective effects of antioxidant coenzyme Q10.

Keywords: UbiAd1 gene expression; coenzyme Q10; local cerebral ischemia; neuroprotection.

MeSH terms

  • Animals
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / metabolism*
  • Cerebral Infarction / drug therapy*
  • Cerebral Infarction / metabolism*
  • Dimethylallyltranstransferase / genetics*
  • Male
  • Neuroprotective Agents / therapeutic use*
  • Rats
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / therapeutic use

Substances

  • Neuroprotective Agents
  • Ubiquinone
  • Dimethylallyltranstransferase
  • coenzyme Q10