A Sorting Statistic with Application in Neurological Magnetic Resonance Imaging of Autism

J Healthc Eng. 2018 Mar 29:2018:8039075. doi: 10.1155/2018/8039075. eCollection 2018.

Abstract

Effect size refers to the assessment of the extent of differences between two groups of samples on a single measurement. Assessing effect size in medical research is typically accomplished with Cohen's d statistic. Cohen's d statistic assumes that average values are good estimators of the position of a distribution of numbers and also assumes Gaussian (or bell-shaped) underlying data distributions. In this paper, we present an alternative evaluative statistic that can quantify differences between two data distributions in a manner that is similar to traditional effect size calculations; however, the proposed approach avoids making assumptions regarding the shape of the underlying data distribution. The proposed sorting statistic is compared with Cohen's d statistic and is demonstrated to be capable of identifying feature measurements of potential interest for which Cohen's d statistic implies the measurement would be of little use. This proposed sorting statistic has been evaluated on a large clinical autism dataset from Boston Children's Hospital, Harvard Medical School, demonstrating that it can potentially play a constructive role in future healthcare technologies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Algorithms
  • Autistic Disorder / diagnostic imaging*
  • Brain / diagnostic imaging*
  • Child
  • Child, Preschool
  • Data Collection
  • Electronic Health Records
  • Healthy Volunteers
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging*
  • Models, Statistical
  • Neuroimaging
  • Normal Distribution
  • Retrospective Studies
  • Young Adult