Acute kidney injury, agranulocytosis, drug-induced liver injury, and posterior reversible encephalopathy syndrome caused by high-dose methotrexate-possible role of low activity ABC and SLC drug transporters

Eur J Clin Pharmacol. 2018 Sep;74(9):1191-1192. doi: 10.1007/s00228-018-2485-6. Epub 2018 May 22.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • ATP-Binding Cassette Transporters / metabolism
  • Acute Kidney Injury / chemically induced
  • Adult
  • Agranulocytosis / chemically induced
  • Antimetabolites, Antineoplastic / administration & dosage
  • Antimetabolites, Antineoplastic / adverse effects*
  • Biological Transport
  • Chemical and Drug Induced Liver Injury / etiology
  • Humans
  • Male
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Pharmacogenetics*
  • Posterior Leukoencephalopathy Syndrome / chemically induced
  • Solute Carrier Proteins / metabolism

Substances

  • ATP-Binding Cassette Transporters
  • Antimetabolites, Antineoplastic
  • Solute Carrier Proteins
  • Methotrexate