Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice

Yukako Yoshikane; Mitsuhisa Koga; Tamaki Cho; Kyoko Imanaka-Yoshida; Yumi Yamamoto; Junichi Hashimoto; Hiroki Aoki; Koichi Yoshimura; Shinichi Hirose

doi:10.1007/978-4-431-54628-3_33

Tissue Remodeling in Vascular Wall in Kawasaki Disease-Related Vasculitis Model Mice

Review

In: Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 33.

2016 Jun 25.

Authors

Yukako Yoshikane¹, Mitsuhisa Koga², Tamaki Cho³, Kyoko Imanaka-Yoshida⁴, Yumi Yamamoto⁵, Junichi Hashimoto⁵, Hiroki Aoki⁶, Koichi Yoshimura¹, Shinichi Hirose¹

Book Editors

Toshio Nakanishi¹, Roger R. Markwald², H.Scott Baldwin³, Bradley B. Keller⁴, Deepak Srivastava⁵, Hiroyuki Yamagishi⁶

Affiliations

¹ Department of Pediatrics, Faculty of Medicine, Fukuoka University, Nanakuma 7-45-1, Jonan-ku, Fukuoka, 814-0180, Japan
² Department of Pharmaceutical Care and Health Sciences, Fukuoka University, Fukuoka, Japan
³ Department of Functional Bioscience, Fukuoka Dental College, Fukuoka, Japan
⁴ Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Japan
⁵ Department of Surgery and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan
⁶ Cardiovascular Research Institute, Kurume University, Kurume, Japan

Book Affiliations

¹ Department of Pediatric Cardiology, Tokyo Women's Medical University, Tokyo, Japan
² Cardiovascular Developmental Biology Center, Medical University of South Carolina Clemson University, Charleston, South Carolina, USA
³ Department of Pediatrics (Cardiology), Vanderbilt University, Nashville, Tennessee, USA
⁴ Pediatrics, Pharmacology and Toxicology, and Bioengineering, University of Louisville, Louisville, Kentucky, USA
⁵ Gladstone Institute of Cardiovascular Disease, San Francisco, California, USA
⁶ Pediatrics, Division of Pediatric Cardiology, Keio University School of Medicine, Tokyo, Japan

Excerpt

Kawasaki disease is the most common acute systemic vasculitis of unknown etiology in children [1] and can cause inflammation of the coronary arteries leading to aneurysms. Tenascin-C, an extracellular matrix protein, and c-Jun N-terminal kinase (JNK), an intracellular signaling protein, are known to be associated with inflammation and tissue remodeling [2, 3]. The purpose of this study was to demonstrate tenascin-C and JNK might be involved in tissue remodeling in a Candida albicans-induced murine model of aneurysm.

Sections

References

Publication types

Review