New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas

Laura A Jowett; Ethan N W Howe; Xin Wu; Nathalie Busschaert; Philip A Gale

doi:10.1002/chem.201801463

New Insights into the Anion Transport Selectivity and Mechanism of Tren-based Tris-(thio)ureas

Chemistry. 2018 Jul 20;24(41):10475-10487. doi: 10.1002/chem.201801463. Epub 2018 Jun 19.

Authors

Laura A Jowett¹, Ethan N W Howe¹, Xin Wu¹, Nathalie Busschaert², Philip A Gale¹

Affiliations

¹ School of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
² Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA.

PMID: 29786913
DOI: 10.1002/chem.201801463

Abstract

The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC₅₀ values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange.

Keywords: anion transport; bicarbonate; chloride; nitrate; sulfate.