The concept of personalized medicine is based upon using personal genetic information to predict individual responses to drug therapy. However, environmental factors such as diet, energy status, gut microbiota, health status and age will influence the expression of one's genetic potential. Metabolomics data from biofluid and tissue sample analysis hold information regarding a patient's genotype and phenotype. Metabolomics data can be rapidly collected from biofluid samples over time, providing temporal metabolic analyses of patient samples. In addition to metabolic markers of a patient's phenotype, metabolomics can provide markers of drug efficacy, toxicity and clearance.
Keywords: biomarkers; genetics; genomics; metabolomics; personalized medicine.