Objective: Introduction: Chronic obstructive pulmonary disease (COPD) is a one of the main reasons of disability and mortality in the world. The essential attention is dedicated to the combination of COPD and erosive/ulcer defects with the haemorrhage risk factor. The aim was to compare gastric acidity and mucoid secretion in patients with chronic obstructive pulmonary disease of gastropathy development.
Patients and methods: Materials and methods: 94 patients with gastroduodenal erosive and ulcerous defects combined with COPD were examined. More than 50 % of patients (over 20 pack-years) had a long smoking history. Control group including 20 healthy voluntiers.
Results: Results: The mean age of patients was no difference in both groups. In regards to the severity of disease based on FEV1 30,9 % patients had mild obstruction and 69,1 % had moderate obstruction. Measurement of intragastric pH in patients with COPD and gastropathy showed the tendency of decreasing pH from 1,70±0,05 to 1,52±0,04 (р<0,05), while the pepsin level increased from 0,56±0,05 mg/ml to 0,86±0,07 mg/ml (р<0,01). At the same time the level of NANA decreased in cases of ulcerative defects (р<0,05).
Conclusion: Conclusions: The COPD combination with gastropathy leads to appearance of numerous erosions and ulcers in gastroduodenal zone that can be the reason of bleeding development. Long-term cigarette smoke exposure and high level of H.pylori infectoin are the main cause of gastroduodenal erosive and ulcerative defects in this comorbidities. The presence of erosions and ulcers is accompanied by a significant increase of an acid-peptic factor and a decrease of defense factor.
Keywords: chronic obstructive pulmonary disease; gastropathy.