Protein Kinase D was involved in vascular remodeling in spontaneously hypertensive rats

Clin Exp Hypertens. 2019;41(4):299-306. doi: 10.1080/10641963.2018.1469647. Epub 2018 May 21.

Abstract

The present study was designed to determine the role of PKD in vascular remodeling (VR) in Spontaneously hypertensive rats (SHRs). Increased SBP, VR and PKD activation were prominent in SHRs. The SBP has a positive correlation with the activation of PKD in SHRs. The ratio of media to lumen (MT/LD), volume fraction of collagen (VFC), hydroxyproline, IL-6, TNF-α and nitrotyrosine content were significantly related to the activated PKD. It may be concluded that PKD plays a central role in VR, and the mechanism may be related to its regulation of hypertrophy, fibrosis, inflammation and oxidative stress.

Keywords: Protein Kinase D; hypertension; vascular remodeling.

MeSH terms

  • Animals
  • Aorta / metabolism*
  • Aorta / pathology*
  • Blood Pressure*
  • Hydroxyproline / metabolism
  • Hypertension / physiopathology
  • Interleukin-6 / metabolism
  • Male
  • Protein Kinase C / metabolism*
  • Rats
  • Rats, Inbred SHR
  • Rats, Inbred WKY
  • Systole
  • Tumor Necrosis Factor-alpha / metabolism
  • Vascular Remodeling*

Substances

  • Il6 protein, rat
  • Interleukin-6
  • Tumor Necrosis Factor-alpha
  • protein kinase D
  • Protein Kinase C
  • Hydroxyproline