Metastatic castration-resistant prostate cancer and the challenge of a patient with chronic kidney disease in hemodialysis

Autops Case Rep. 2018 Apr 18;8(2):e2018011. doi: 10.4322/acr.2018.011. eCollection 2018 Apr-Jun.

Abstract

At a time when the population shows increasing longevity, entities such as cancer and chronic kidney disease (CKD) are more frequently connected. In the United States, approximately 6% of the patients on hemodialysis have cancer. The challenge to manage oncologic patients with CKD in a hemodialytic program represents a great shortage of available information on the choice of the best drug, timing, dosage adjustments, dialysis method, and treatment safety. We present the case of a patient with prostate cancer and terminal CKD in hemodialysis, and the treatment sequence after the development of resistance to hormonal blockade therapy, which included docetaxel, enzalutamide, and radium-223.

Keywords: Dialysis; Docetaxel; Enzalutamide; Prostate cancer; Radium-223.

Publication types

  • Case Reports