Hepatitis C Virus Diagnosis and the Holy Grail

Infect Dis Clin North Am. 2018 Jun;32(2):425-445. doi: 10.1016/j.idc.2018.02.010.

Abstract

The world has embraced the call for global elimination of hepatitis C virus by 2030. The unprecedented speed of therapeutic development and increased access to direct-acting antivirals has made elimination a possibility. We must screen hundreds of millions of people to diagnose and treat those currently infected. Global access to hepatitis C virus diagnostics will be a keystone to success. Key challenges must be overcome and systems optimized to ensure widespread access to existing diagnostics. Although promising technologies may soon transform the landscape, innovative strategies are needed to stimulate investment and accelerate the development of point-of-care hepatitis C virus diagnostics.

Keywords: Diagnostics; HCV; HCV elimination; Models of care; Point-of-care; Rapid; Simplified; Test and treat.

Publication types

  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • Disease Eradication / instrumentation
  • Disease Eradication / methods
  • Global Health
  • Hepacivirus / drug effects
  • Hepacivirus / genetics
  • Hepacivirus / isolation & purification*
  • Hepatitis C / diagnosis*
  • Hepatitis C / drug therapy
  • Hepatitis C / epidemiology
  • Humans
  • Molecular Diagnostic Techniques / economics
  • Molecular Diagnostic Techniques / methods
  • Molecular Diagnostic Techniques / trends*
  • Point-of-Care Systems*
  • Substance Abuse, Intravenous / complications
  • Substance Abuse, Intravenous / virology

Substances

  • Antiviral Agents