[The expressions and correlations of IL-10, CD14 and CD68 in laryngal squamous cell carcinoma]

Abstract

Objective:The aim of this study is to investigate the distribution of IL-10, CD14 and CD68 in the tumor microenvironment of LSCC with the clinicopathologic factors. Method:We detected the expressions of IL-10, CD14 and CD68 in 46 primary LSCC tumor tissues by immunohistochemistry staining and explore the relationship between them and clinicopathologic factors. Result:We found that the expressions of IL-10, CD14 and CD68 were significantly correlated with clinical stage and T stage (P<0.01). IL-10 and CD14 were correlated with lymph node metastasis (P<0.01), and CD68 was correlated with pathological differentiation (P<0.05). There is a positive correlation trend between the expression of IL-10 and CD14 (P<0.01). Conclusion:We confirm that the high level expressions of IL-10, monocytes and TAMs contribute to the tumor development of LSCC and there is a positive correlation between the expression of IL-10 and monocytes.

Keywords: CD14; CD68; IL-10; immunohistochemistry; laryngeal neoplasms squamous cell cancer.