Abstract
The glutaraldehyde fixation technique for bioprosthetic tissue valves has been used for about 30 years. It is more or less generally recognized, however, that a solution to the ongoing problems of calcification and immunomodulated inflammation can only be achieved with the development of alternative fixation techniques that differ from fixation with glutaraldehyde. This review reports on the chemistry behind newly developed tissue-fixation processes and the preliminary results achieved with these.
MeSH terms
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Alkylating Agents / chemistry
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Animals
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Bioprosthesis*
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Bone Density Conservation Agents / chemistry
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Calcinosis / immunology
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Calcinosis / prevention & control
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Carbodiimides / chemistry
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Cross-Linking Reagents / chemistry
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Epoxy Compounds / chemistry
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Fixatives / chemistry
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Glutaral / chemistry
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Heart Valve Prosthesis*
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Humans
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Inflammation / immunology
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Inflammation / prevention & control
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Oxidation-Reduction
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Photochemical Processes
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Schiff Bases
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Tissue Engineering
Substances
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Alkylating Agents
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Bone Density Conservation Agents
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Carbodiimides
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Cross-Linking Reagents
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Epoxy Compounds
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Fixatives
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Schiff Bases
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Glutaral