Incidental Detection of Dent-2 Disease in an Infant with Febrile Proteinuria

Med Princ Pract. 2018;27(4):392-395. doi: 10.1159/000490147. Epub 2018 May 17.

Abstract

Objective: Febrile proteinuria is functional proteinuria and is seen as a transitory phenomenon during acute febrile illness, mainly viral infections. It is a benign phenomenon and clears promptly with resolution of the infection.

Clinical presentation and intervention: In this report, we present a patient who was thought to have febrile proteinuria. Persistence of significant proteinuria after resolution of the infection prompted biochemical and genetic workup which led to the diagnosis of Dent-2 disease.

Conclusion: We recommend the use of SDS-PAGE (sodium dodecyl sulfate electropheresis) for the detection of low molecular weight proteinuria.

Keywords: Dent-2 disease; Functional proteinuria; Infants; OCRL mutation; SDS-PAGE.

Publication types

  • Case Reports

MeSH terms

  • Blood Protein Electrophoresis
  • Fever / complications
  • Genetic Diseases, X-Linked / complications*
  • Genetic Diseases, X-Linked / diagnosis*
  • Humans
  • Infant
  • Male
  • Nephrolithiasis / complications*
  • Nephrolithiasis / diagnosis*
  • Proteinuria / diagnosis
  • Proteinuria / etiology*

Supplementary concepts

  • Dent Disease 2