Antitumor aporphine alkaloids from Thalictrum wangii

Qiong Jin; Dong Yang; Zhi Dai; Afsar Khan; Bei Wang; Xin Wei; Ying Sun; Yun-Li Zhao; Yi-Fen Wang; Ya-Ping Liu; Xu-Dong Zhao; Xiao-Dong Luo

doi:10.1016/j.fitote.2018.05.012

Antitumor aporphine alkaloids from Thalictrum wangii

Fitoterapia. 2018 Jul:128:204-212. doi: 10.1016/j.fitote.2018.05.012. Epub 2018 May 24.

Authors

Qiong Jin¹, Dong Yang², Zhi Dai², Afsar Khan³, Bei Wang⁴, Xin Wei⁴, Ying Sun⁵, Yun-Li Zhao⁶, Yi-Fen Wang⁶, Ya-Ping Liu⁶, Xu-Dong Zhao⁷, Xiao-Dong Luo⁸

Affiliations

¹ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China.
² Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
³ Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
⁴ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China; University of Chinese Academy of Sciences, Beijing 100049, PR China.
⁵ School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China.
⁷ Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Kunming 650223, Yunnan, PR China. Electronic address: zhaoxudong@mail.kiz.ac.cn.
⁸ Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences/Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming, 650201, PR China. Electronic address: xdluo@mail.kib.ac.cn.

PMID: 29772303
DOI: 10.1016/j.fitote.2018.05.012

Abstract

Nine new isoquinoline alkaloids, including two proaporphine (1-2), three aporphine (3-5), two oxoaporphine (6-7), and two seco-bisbenzylisoquinoline (8-9), together with three known alkaloids (10-12) were isolated from the whole plant of Thalictrum wangii. Their structures were established on the basis of spectroscopic data. The antitumor activities of the isolated compounds were evaluated in vitro against glioma stem cells. Compounds 3-8 showed the cytotoxicity with IC₅₀ values 15-20 μg/mL.

Keywords: Antitumor; Aporphine alkaloids; Glioma stem cells; Thalictrum wangii.

MeSH terms

Alkaloids / isolation & purification*
Alkaloids / pharmacology
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Aporphines / isolation & purification*
Aporphines / pharmacology
Cell Line, Tumor
Glioma
HEK293 Cells
Humans
Molecular Structure
Neoplastic Stem Cells / drug effects
Thalictrum / chemistry*

Substances

Alkaloids
Antineoplastic Agents, Phytogenic
Aporphines