Objective: To investigate the correlation between three-dimensional echocardiography and the expressions of hypoxia-inducible factor-1 alpha (HIF-1α), heme oxygenase 1 (HO-1) and vascular endothelial growth factor (VEGF) in patients with myocardial infarction.
Patients and methods: A total of 40 patients with acute myocardial infarction treated with three-dimensional echocardiography and 40 patients receiving normal physical examination were selected. According to whether the disease occurred, they were divided into the myocardial infarction group and the normal group. Relevant indexes of two-dimensional and three-dimensional echocardiography and the expressions of HO-1, HIF-1α and VEGF in the myocardial infarction group and the normal group were compared. Besides, the correlation of the left ventricular ejection fraction (LVEF) measured by three-dimensional echocardiography with HIF-1α area, HO-1 area and VEGF area was analyzed.
Results: The left ventricular end-diastolic diameter (LVEDD) in the myocardial infarction group was significantly larger than that in the normal group (p<0.05), while the left ventricular inferior wall thickness (LVIWT) and LVEF in the myocardial infarction group were significantly smaller than those in the normal group (p<0.05). The global end-diastolic volume (GEDV) and global end-systolic volume (GESV) measured by three-dimensional echocardiography in the myocardial infarction group were significantly higher than those in the normal group (p<0.05), while the level of GEF in the myocardial infarction group was lower than that in the normal group; the levels of HIF-1α, HO-1 and VEGF in the myocardial infarction group were significantly higher than those in normal group (p<0.05). LVEF measured by three-dimensional echocardiography was negatively correlated with HIF-1α area, HO-1 area and VEGF area (p<0.05).
Conclusions: Three-dimensional echocardiography significantly improves the diagnostic value of patients with myocardial infarction, and its index, LVEF, is negatively correlated with the expressions of serum HIF-1α, HO-1 and VEGF, which can be used for evaluating cardiac functions and predicting the prognosis of patients.