Metal-Free C(sp3)-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex

Yang Li; Jing Zhang; Defang Li; Yiyun Chen

doi:10.1021/acs.orglett.8b01172

Metal-Free C(sp³)-H Allylation via Aryl Carboxyl Radicals Enabled by Donor-Acceptor Complex

Org Lett. 2018 Jun 1;20(11):3296-3299. doi: 10.1021/acs.orglett.8b01172. Epub 2018 May 16.

Authors

Yang Li¹, Jing Zhang¹, Defang Li^{1

2}, Yiyun Chen^{1

2}

Affiliations

¹ State Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry , University of Chinese Academy of Sciences, Chinese Academy of Sciences , 345 Lingling Road , Shanghai 200032 , China.
² School of Physical Science and Technology , ShanghaiTech University , 100 Haike Road , Shanghai 201210 , China.

PMID: 29767989
DOI: 10.1021/acs.orglett.8b01172

Abstract

The first aryl carboxyl radical generation by the donor-acceptor complex with N-acyloxyphthalimides and Hantzsch esters is reported. Regio- and chemoselective C(sp³)-H bond allylation is enabled by aryl carboxyl radicals with visible light irradiation under mild and metal-free conditions.

Publication types

Research Support, Non-U.S. Gov't