N-Heterocyclic Carbene-Catalyzed Annulation of Ylides with Ynals: Direct Access to α-Pyrones

Ming Lang; Qianfa Jia; Jian Wang

doi:10.1002/asia.201800595

N-Heterocyclic Carbene-Catalyzed Annulation of Ylides with Ynals: Direct Access to α-Pyrones

Chem Asian J. 2018 Sep 4;13(17):2427-2430. doi: 10.1002/asia.201800595. Epub 2018 Jun 19.

Authors

Ming Lang¹, Qianfa Jia¹, Jian Wang¹

Affiliation

¹ School of Pharmaceutical Sciences, Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing, 100084, P. R. China.

PMID: 29767480
DOI: 10.1002/asia.201800595

Abstract

We herein report an N-Heterocyclic Carbene (NHC)-catalyzed annulation of ylides with ynals that provides an efficient protocol to make 4,6-disubstituted α-pyrones. This method affords a variety of α-pyrones in good to high yields as well as broad substrate scope and good functional group tolerance.

Keywords: cyclization; heterocycles; organocatalysis; pyrones; ylides.