Abstract
In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the design and synthesis of new molecules with potential application in several diseases was highlighted. Organic synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a wide range of structural modifications for structure-activity relationship studies and improving or modulating the biological activity of the promising compounds.
Keywords:
Polyphenols; anticancer; chemical synthesis; drugs; medicinal chemistry; polyphenol metabolites..
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Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arachidonate 5-Lipoxygenase / metabolism
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Biological Products / chemistry
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Biological Products / metabolism
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Biological Products / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / metabolism
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Enzyme Inhibitors / pharmacology*
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Humans
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Molecular Structure
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Neoplasms / drug therapy*
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Neoplasms / metabolism
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Neoplasms / pathology
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Polyphenols / chemistry
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Polyphenols / metabolism
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Polyphenols / pharmacology*
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Protein Kinases / metabolism
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Telomerase / antagonists & inhibitors
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Telomerase / metabolism
Substances
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Biological Products
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Enzyme Inhibitors
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Polyphenols
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Arachidonate 5-Lipoxygenase
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Protein Kinases
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Telomerase