Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

Adrian Achuthan; Ming-Chin Lee; Reem Saleh; Andrew J Fleetwood; John A Hamilton; Andrew D Cook

doi:10.1007/978-1-4939-7837-3_20

Cytokine-Induced Acute Inflammatory Monoarticular Arthritis

Methods Mol Biol. 2018:1784:215-223. doi: 10.1007/978-1-4939-7837-3_20.

Authors

Adrian Achuthan¹, Ming-Chin Lee², Reem Saleh², Andrew J Fleetwood², John A Hamilton², Andrew D Cook²

Affiliations

¹ Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia. aaa@unimelb.edu.au.
² Department of Medicine, Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

PMID: 29761402
DOI: 10.1007/978-1-4939-7837-3_20

Abstract

Animal models of arthritis enable us to investigate the pathogenesis of the disease and also to evaluate new therapies. Here we describe two different acute inflammatory monoarticular arthritis models (mBSA/IL1β and mBSA/GM-CSF) providing a more rapid and potentially simplified approach to investigate the pathogenesis.

Keywords: Arthritis animal models; Inflammatory arthritis; Rheumatoid arthritis; mBSA/GM-CSF; mBSA/IL1β.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arthritis, Experimental / chemically induced
Arthritis, Experimental / genetics*
Arthritis, Experimental / pathology
Cytokines / toxicity*
Disease Models, Animal
Granulocyte-Macrophage Colony-Stimulating Factor / genetics
Humans
Inflammation / chemically induced
Inflammation / genetics*
Inflammation / pathology
Mice
Rheumatic Fever / chemically induced
Rheumatic Fever / genetics*
Rheumatic Fever / pathology

Substances

Cytokines
Granulocyte-Macrophage Colony-Stimulating Factor