Abstract
A colistin-resistant Escherichia coli isolate from a commercial poultry farm in China carried two colistin resistance genes, mcr-1 and variant of mcr-3, in an IncP plasmid. The variant of the mcr-3 gene, named mcr-3.11, encoded two amino acid substitutions compared with the mcr-3 gene. A novel genetic structure, ISKpn40-mcr-3-dgkA-ISKpn40, might be the key element mediating the translocation of mcr-3 through the formation of a circular form. The mcr-1 and mcr-3 genes, which are colocated on a plasmid, might pose a huge threat to public health.
Keywords:
Escherichia coli; circular form; colistin; mcr-1; mcr-3.
Copyright © 2018 American Society for Microbiology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents
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Chickens
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Colistin / pharmacology*
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Drug Resistance, Bacterial
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Escherichia coli / drug effects*
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Escherichia coli / genetics
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Escherichia coli / metabolism*
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Escherichia coli Proteins / genetics
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Escherichia coli Proteins / metabolism*
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Farms
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Microbial Sensitivity Tests
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Plasmids / genetics*
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Polymyxins / pharmacology*
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Transferases (Other Substituted Phosphate Groups) / genetics
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Transferases (Other Substituted Phosphate Groups) / metabolism
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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MCR-1 protein, E coli
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Polymyxins
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MCR-3 protein, E coli
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Transferases (Other Substituted Phosphate Groups)
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Colistin