Drugs Used in Narcolepsy and Other Hypersomnias

Abstract

Narcolepsy and idiopathic hypersomnia cannot be cured; all available treatments are symptomatic. It is of paramount importance for patients, and their relatives, to be informed about the consequences of these chronic diseases and to become ready to accept the consequences of the diagnosis before starting any treatment. This facilitates the implementation of behavioral modifications and the proper use of medication to decrease the disease burden. A supportive social environment (eg, family members, friends, employer, colleagues, and patient support groups) is instrumental. Current treatment options are discussed with a focus on pharmacologic treatment, including future directions.

Keywords: Idiopathic hypersomnia; Narcolepsy; Nonpharmacological treatment; Pharmacologic treatment; Pitolisant; Sodium oxybate; Stimulants.