1 1Anaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
2 2Critical Care Research Area, National Institute for Health Research Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
3 3Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
4 4Department of Anaesthesia and Critical Care Medicine, Plymouth Hospitals NHS trust Hospital, Plymouth, UK.
5 5Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
6 6Departments of Perioperative and Critical Care Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
7 7Department of Anaesthesia and Critical Care Medicine, Torbay Hospital, Torquay, UK.