How Can Xenosensors Act in Chemical Detoxification Metabolism?

Dongsheng Che; Mohammed Hamdy Farouk; Ibrahim Abd El-Razek; Adams Seidu; Naydia Ekua Ekuful; Guixin Qin; Hailong Jiang; Lianyu Yang

doi:10.2174/1389203719666180514144955

How Can Xenosensors Act in Chemical Detoxification Metabolism?

Curr Protein Pept Sci. 2019;20(2):172-183. doi: 10.2174/1389203719666180514144955.

Authors

Dongsheng Che^{1

2

3}, Mohammed Hamdy Farouk^{1

2

3

4}, Ibrahim Abd El-Razek⁵, Adams Seidu^{1

2}, Naydia Ekua Ekuful^{1

2}, Guixin Qin^{1

2

3}, Hailong Jiang^{1

2

3}, Lianyu Yang^{1

2

3}

Affiliations

¹ College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
² Jilin Provincial Key Lab of Animal Nutrition and Feed Science, Jilin Agricultural University, Changchun, China.
³ Key Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Changchun, China.
⁴ Animal Production Department, Faculty of Agriculture, Al-Azhar University, Cairo, Egypt.
⁵ Animal Production Department, Faculty of Agriculture, Kafrelsheikh University, Kafr Elsheikh, Egypt.

PMID: 29756572
DOI: 10.2174/1389203719666180514144955

Abstract

There are some disparities between pharmacological and toxicological xenobiotic receptor (xenosensors) pathways. These variations include receptor models that indicate several toxic patterns. Such models have demanded some update from traditional medical receptor relations studied by pharmacologists. These may include the response time, the molecular level, and unclear directions of toxicological metabolism. Xenosensors activities were affected by many factors that include genetic elements, physiological status, xenobiotic complication, and species-specific variations. Thus, this review aims to highlight the most advanced features of xenosensors related to toxicant biotransformations and other patterns such as characteristics, recognition, and the relations between different xenosensors.

Keywords: AhR; Xenosensors; detoxification; nuclear receptors; species variations; toxic metabolism..

Publication types

Review

MeSH terms

Animals
Biotransformation
Hazardous Substances / metabolism*
Humans
Inactivation, Metabolic
Receptors, Cytoplasmic and Nuclear / metabolism*
Species Specificity
Xenobiotics / metabolism*

Substances

Hazardous Substances
Receptors, Cytoplasmic and Nuclear
Xenobiotics