Objective:: To describe a case of leucine-rich, glioma inactivated 1 antibody-encephalitis presenting with psychosis.
Methods:: Case report.
Results:: A young man with leucine-rich, glioma inactivated 1-antibody encephalitis initially presented with acute psychotic symptoms, short-term memory loss and faciobrachial dystonic seizures. Magnetic resonance imaging revealed hippocampal lesions. Electroencephalography revealed frontotemporal slowing of background activity.
Conclusion:: Increased awareness of leucine-rich, glioma inactivated 1-antibody encephalitis may promote early recognition and treatment.
Keywords: LGI1 antibody encephalitis; misdiagnosis; psychosis.