Increased Uptake of AV-1451 in a Subacute Infarction Lesion

Yonsei Med J. 2018 Jun;59(4):563-565. doi: 10.3349/ymj.2018.59.4.563.

Abstract

¹⁸F-AV-1451 is a tau PET ligand that has high affinity for paired helical filament tau. However, various off-target bindings unrelated to tau have also been reported. Herein, we report a case of 83-year-old woman, who showed abnormal uptake of AV-1451 that was shown to be subacute infarction. Clinicians should recognize that increased uptake of AV-1451 may be related to stroke.

Keywords: blood-brain-barrier; subacute infarction; tau; ¹⁸F-AV-1451 PET.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • Brain / diagnostic imaging*
  • Brain / metabolism
  • Carbolines / metabolism*
  • Female
  • Humans
  • Infarction / diagnostic imaging*
  • Male
  • Positron-Emission Tomography / methods*
  • Radiopharmaceuticals
  • tau Proteins / metabolism*

Substances

  • Carbolines
  • Radiopharmaceuticals
  • tau Proteins
  • 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole