This is in reply to the Letter by Kahathuduwa et al. titled "Unaccounted for regression to the mean renders conclusion of article titled 'Uric acid lowering in relation to HbA1c reductions with the SGLT2 inhibitor Tofogliflozin' unsubstantiated"

Affiliations

• ¹ Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
• ² Department of Internal Medicine, Oarai Coast Core Clinic, Ibaraki, Japan.
• ³ Clinical Data Science Department, Kowa Company, Ltd., Tokyo, Japan.
• ⁴ Medical Information and Product Advancement Department, Kowa Pharmaceutical Company, Ltd, Tokyo, Japan.
• ⁵ Division of Geriatric Medicine, Department of General Medicine and Health Science, Nippon Medical School, Tokyo, Japan.
• ⁶ Department of General Medicine and Health Science, Nippon Medical School, Tokyo, Japan.
• ⁷ Department of General Internal Medicine, Kawasaki Medical School, Okayama, Japan.