3D Hybrid Small Scale Devices

Jayson V Pagaduan; Anil Bhatta; Lewis H Romer; David H Gracias

doi:10.1002/smll.201702497

3D Hybrid Small Scale Devices

Small. 2018 Jul;14(27):e1702497. doi: 10.1002/smll.201702497. Epub 2018 May 10.

Authors

Jayson V Pagaduan^{1

2}, Anil Bhatta^{1

2}, Lewis H Romer^{2

3}, David H Gracias^{1

4}

Affiliations

¹ Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.
² Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD, 21287, USA.
³ Department of Cell Biology, Department of Biomedical Engineering, Department of Pediatrics and the Center for Cell Dynamics, Johns Hopkins University, Baltimore, MD, 21287, USA.
⁴ Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA.

PMID: 29749014
DOI: 10.1002/smll.201702497

Abstract

Interfacing nano/microscale elements with biological components in 3D contexts opens new possibilities for mimicry, bionics, and augmentation of organismically and anatomically inspired materials. Abiotic nanoscale elements such as plasmonic nanostructures, piezoelectric ribbons, and thin film semiconductor devices interact with electromagnetic fields to facilitate advanced capabilities such as communication at a distance, digital feedback loops, logic, and memory. Biological components such as proteins, polynucleotides, cells, and organs feature complex chemical synthetic networks that can regulate growth, change shape, adapt, and regenerate. Abiotic and biotic components can be integrated in all three dimensions in a well-ordered and programmed manner with high tunability, versatility, and resolution to produce radically new materials and hybrid devices such as sensor fabrics, anatomically mimetic microfluidic modules, artificial tissues, smart prostheses, and bionic devices. In this critical Review, applications of small scale devices in 3D hybrid integration, biomicrofluidics, advanced prostheses, and bionic organs are discussed.

Keywords: biomedical engineering; bionics; microtechnology; nanotechnology; robotics.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.