Redox-Responsive Polymer with Self-Immolative Linkers for the Release of Payloads

Supitchaya Iamsaard; Farzad Seidi; Naruphorn Dararatana; Daniel Crespy

doi:10.1002/marc.201800071

Redox-Responsive Polymer with Self-Immolative Linkers for the Release of Payloads

Macromol Rapid Commun. 2018 Jun;39(12):e1800071. doi: 10.1002/marc.201800071. Epub 2018 May 11.

Authors

Supitchaya Iamsaard¹, Farzad Seidi¹, Naruphorn Dararatana¹, Daniel Crespy¹

Affiliation

¹ Department of Materials Science and Engineering, School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology (VISTEC), Rayong, 21210, Thailand.

PMID: 29748982
DOI: 10.1002/marc.201800071

Abstract

Previous couplings of corrosion inhibitors to redox-responsive polymers via covalent bonding suffer from several drawbacks. It is presented here novel redox-responsive polymer-corrosion inhibitor conjugates that contain self-immolative linkers in their side chains. Very fast redox-induced release of tryptamine, a drug and a corrosion inhibitor, is observed after applying a reductive trigger.

Keywords: controlled release; redox-responsive polymers; self-immolative linker; stimuli-responsive materials; tryptamine.

MeSH terms

Drug Carriers / chemistry*
Drug Delivery Systems / methods*
Drug Liberation*
Oxidation-Reduction
Polymers / chemistry*
Temperature
Tryptamines / administration & dosage
Tryptamines / chemistry
Tryptamines / pharmacokinetics

Substances

Drug Carriers
Polymers
Tryptamines
tryptamine