An Overview of PET Radiochemistry, Part 2: Radiometals

Marie Brandt; Jens Cardinale; Margaret L Aulsebrook; Gilles Gasser; Thomas L Mindt

doi:10.2967/jnumed.117.190801

An Overview of PET Radiochemistry, Part 2: Radiometals

J Nucl Med. 2018 Oct;59(10):1500-1506. doi: 10.2967/jnumed.117.190801. Epub 2018 May 10.

Authors

Marie Brandt^{1

2}, Jens Cardinale^{1

2}, Margaret L Aulsebrook³, Gilles Gasser³, Thomas L Mindt^{4

2}

Affiliations

¹ Ludwig Boltzmann Institute Applied Diagnostics, General Hospital of Vienna, Vienna, Austria.
² Department of Biomedical Imaging and Image Guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria; and.
³ Chimie ParisTech, PSL University, Laboratory for Inorganic Chemical Biology, Paris, France.
⁴ Ludwig Boltzmann Institute Applied Diagnostics, General Hospital of Vienna, Vienna, Austria thomas.mindt@lbiad.lbg.ac.at.

PMID: 29748237
DOI: 10.2967/jnumed.117.190801

Abstract

This continuing educational review provides an overview on radiometals used for PET. General aspects of radiometal-based radiotracers are covered, and the most frequently applied metallic PET radionuclides, ⁶⁸Ga, ⁸⁹Zr, and ⁶⁴Cu, are highlighted with a discussion of their strengths and limitations.

Keywords: 64Cu; 68Ga; 89Zr; metallic PET radionuclides; theranostics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Nuclear Medicine
Positron-Emission Tomography*
Radiochemistry*
Radioisotopes / chemistry

Substances

Radioisotopes