Retinal degeneration (RD) is a common eye disease which may result in blindness. At present, there is no effective clinical treatment for RD. It is known that apoptosis causes the occurrence and development of retinal degeneration, therefore antiapoptotic/antioxidative treatment has always been the focus in the treatment of RD. There are many kinds of antioxidant drugs, among which natural antioxidants are featured with reliable sources, high safety and less side effects. Hence researchers across the world made tremendous efforts in finding the safe and effective natural antioxidants. This paper focuses on the research progress of natural antioxidants in the treatment of retinal degeneration, in an effort to provide some valuable reference for clinical research. (Chin J Ophthalmol, 2018, 54: 312-315).
视网膜退行性变性是一类常见的眼部进行性、致盲性眼部疾病，目前临床尚无有效的治疗方法。由于凋亡是视网膜退行性变性发生、发展的共同转归，因此针对抗凋亡和抗氧化的研究一直备受临床关注。抗氧化药物种类繁多，其中天然抗氧化剂具有来源可靠、安全性高、不良反应低等优点，因此寻求安全有效的天然抗氧化剂及其给药方式成为国内外学者研究的热点。本文重点介绍天然抗氧化物质治疗视网膜退行性变性的研究进展，并对其应用前景进行展望，以期为临床相关研究提供参考。（中华眼科杂志，2018，54：312-315）.
Keywords: Antioxidants; Ascorbic acid; Carotenoids; Polyphenols; Retinal degeneration; Vitamin A.