Objective: To explore the relationship between smoking and hyperuricemia in Chinese residents. Methods: Based on data from the China Health and Nutrition Survey (CHNS), residents with blood samples provided in the 2009 round (including information of socio-demographic factors, lifestyle behaviors, medical history, and laboratory examinations etc.) were selected as the participants in the current analysis. Unconditional logistic regression models were utilized to compute the ORs and corresponding 95%CIs for assessing the relationship between smoking and hyperuricemia. Results: Among the 8 785 subjects, 1 435 had hyperuricemia with a prevalence rate of 16.3%, consisting of 886 men and 549 women with prevalence rates of 21.6% (886/4 110) and 11.7% (549/4 675) , respectively. Compared with never smokers, the adjusted OR (95%CI) for hyperuricemia was 0.83 (0.70-0.98) among current smokers, 0.77 (0.63-0.94) among current smokers with 20-39 years of smoking, and 0.79 (0.65-0.97) among current smokers with 11-20 cigarettes per day. When stratified by gender and compared with non-smoker, the adjusted OR (95%CI) for hyperuricemia among current smokers compared with never smokers was 0.83 (0.70-0.98) among men, while no significant association was found in female current smokers (OR=0.73, 95%CI: 0.42-1.26, P=0.260). Conclusion: In Chinese residents, there is an inverse association between smoking and hyperuricemia prevalence, and this association may be related to duration and intensity of smoking among current smokers. The findings need to be validated in large prospective cohort studies.
目的： 探究我国居民吸烟与高尿酸血症之间的关系。 方法： 利用"中国居民健康与营养调查"（CHNS）数据，选取2009年调查中有采集血样并一般社会人口学特征、个人生活习惯、疾病史和实验室检测等信息完整的8 785名居民作为研究对象进行横断面分析。应用非条件logistic回归模型计算相关因素的OR（95% CI）值。 结果： 在8 785名研究对象中，共有高尿酸血症患者1 435例，患病率为16.3%，其中男性患病率为21.6%（886/4 110），女性患病率为11.7%（549/4 675）。校正混杂因素后发现，与从不吸烟者相比，现在吸烟个体患高尿酸血症的OR=0.83, 95% CI: 0.70~0.98；现在吸烟者中，吸烟年限为20~39年（OR=0.77, 95% CI: 0.63~0.94）、每日吸烟支数11~20支（OR=0.79, 95% CI: 0.65~0.97）与高尿酸血症患病率相关。进一步按性别分层后发现，与从不吸烟者相比，男性现在吸烟者患高尿酸血症的OR=0.83, 95% CI: 0.70~0.98，而在女性现在吸烟者中差异无统计学意义（OR=0.73, 95% CI: 0.42~1.26; P=0.260）。 结论： 在我国居民中，吸烟与高尿酸血症患病率呈负相关关系，现在吸烟者中吸烟年限及每日吸烟支数对我国居民高尿酸血症的影响仍需要在大样本前瞻性队列研究中进行验证。.
Keywords: CHNS; Hyperuricemia; Smoking; Uric acid.